It was first made in 1893 by a Japanese chemist (Nagai Nagayoshi) from ephedrine.
In 1919 Akira Ogata made crystallized meth.
By 1944 the FDA had approved methamphetamine (desoxyn) as treatment for:
- Post encephalitic parkinsonism
- Hay fever
- Cerebral arteriosclerosis
Later approvals were removed. At this time methamphetamine is FDA approved for ADHD (attention deficit hyperactivity disorder) and short term obesity (a few weeks).
During World War II meth was used by military on both sides of the Atlantic keeping soldiers fighting when under exhaustion from lack of sleep and hunger. The Germans dispensed it under the name Pervitin
Meth has been used in bronchial inhalers and decongestants. It is a more potent stimulant than amphetamine because at comparable levels crank is absorb into the brain much quicker and its harmful effects on the central nervous system longer lasting.
Ingesting methamphetamine releases a sudden and massive surge of neurotransmitters in the brain.
- Serotonin (mood swings such as depression, being anxious)
- Norepinephrine (arousal, flight or fight response)
- Dopamine (feelings of pleasure, euphoria)
Addiction occurs rapidly and as tolerance builds up an ever increasing dosage is needed to achieve the same effect.
One of the most distinguishing signs of methamphetamine use is the chemical smell on the breath (bad breath odor). Long-term meth use can result in what is known as meth mouth.
What is Meth Mouth
This is tooth decay on a massive scale. Teeth become blackened, rotted and may eventually fall out. Restoration may not be possible. Meth mouth is no where more evident than in our nations prisons.
The American Dental Association warns parents and dentists to be concerned about teenagers and young adults who show sudden and unexplained tooth decay. Since meth